I do it all the time, assessing trustworthiness in a heuristic fashion. Game looks legit, website clearly belongs to who it says it belongs to, etc.
What really does itch.io or Steam offer in the way of protection if a developer wants to be malicious anyway?
P.S: This game and its sequel are really good, and as far as I'm aware this is the only distribution point: https://silverspaceship.com/promesst/