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It may be worthwhile looking at Shen (a similar lisp-like langauge) which targets translation to JS. I haven't checked in on their progress in a while, but it seems the largest implementation hurdle is tail recursion.

shen is http://www.shenlanguage.org/

And of you course you can't talk about compile-to-JS lisps these days without mentioning ClojureScript ;)

ClojureScript is amazing, and makes sense for a lot of apps because it's so feature full.

It looks really interesting!

Deleted comment

Care to elaborate?