I went with 19" rack gear [1] instead of Series 500.
As mic I use an SM57 which is fed into a DBX 286 compressor/de-esser/gate/enhancer and that signal is going to the videoconferencing application and is looped back into my headphones. The neat thing about the 286 is that it's fully analog so I can still hear myself with zero latency.
For the return signal from the videoconference I have a seperate audio interface that feeds into a Behringer Autocomp to compress practically all the dynamic range out of it and then it's going to a t.c. electric finalizer to do some multiband compression which fixes most midrange heavy gaming headsets.
This gear also has a dual purpose as outboard gear for audio production stuffs though, it's not just for the video conferencing.