1. Performance is very very rarely a contributor to a product success. Users prefer more features over more performant app all the time (both directly when asked and indirectly by what products they choose).
2. Rendering/client computation speed is rarely a contributor to real and perceived performance. It's almost always the async calls - how many you have, and how long they take. It's almost always a waste of effort to try and make your framework render at half the time when 99% of your lag is a database call.
3. Framework performance is rarely a contributor to the speed of your rendering. It's most often a problem with how you structured your app. You can structure your app poorly in any framework. (I would hazard a guess that in your panel switch example a differently structured React+MobX solution would not have the problem you described)
4. There are only very few scenarios where the rendering speed between frameworks makes a perceptible difference (usually when talking about large tables or similar scenarios), in all other cases it's a difference of a few milliseconds.