They're doing threading without the GIL, which means it's not compatible with existing C extensions.
CPython is also building a -no-gil compile-time option. If that gets traction, some of the big performance-oriented C extensions like Numpy etc would likely build a non-GIL extension version too.
Then, if RustPython's non-GIL implementation is compatible with CPython's, and their C ABI is compatible, those C extensions might work.