If they support python packages exposing the C ABI and expose a C ABI for embedding, I can't see why not.
CPython is also building a -no-gil compile-time option. If that gets traction, some of the big performance-oriented C extensions like Numpy etc would likely build a non-GIL extension version too.
Then, if RustPython's non-GIL implementation is compatible with CPython's, and their C ABI is compatible, those C extensions might work.
1. releasing the gil means multithreading is opt-in for a given code section in NumPy. Only very specific parts of the code need to be threadsafe.
2. not relying on a gil in cpython runtime means multithreading becomes opt out. Now all the code by default needs to be threadsafe, including the libs you depend on.
A lot of C/C++/Fortran scientific code is not thread safe, and the whole scientific python ecosystem depends heavily on those codebases.A quick check on master shows only 10-20 calls using NPY_BEGIN_ALLOW_THREADS (which is an alias to Py_BEGIN_ALLOW_THREADS).
A lot of the NumPy code manipulates python runtime objects, and doing so without thread safety would likely break everywhere. A lot of efforts would be needed to gradually make large C extension thread safe.