You could implement a HTML renderer with Collagraph (https://github.com/fork-tongue/collagraph).

From the README: Write your Python interfaces in a declarative manner with plain render functions, component classes or even single-file components using Vue-like syntax, but with Python!

  - Reactivity (made possible by leveraging observ)
  - Function components
  - Class components with local state and life-cycle methods/hooks
  - Single-file components with Vue-like syntax (.cgx files)
  - Custom renderers

yes

https://github.com/gvanrossum/pyxl3