I run i3, so practically everything I do is driven by keyboard shortcuts. On Windows I use AutoHotKey to achieve a similar level of support when I have to use it.

To avoid collisions I'll often bind a single key to something like "Control + Shift + Alt + Meta + F14". No application I'm aware of goes hirer than F12 and most keyboard combos require a max of 3 keys. By binding such a ridiculous number of keys to one key I don't have to contort my hand too much and I can still always find the mute key.

Often the key will trigger a script, and the script will use information such as the active window to understand the exact output. (If Zoom mute is Space, if Teams it is Ctrl+Shift+M because of course it is, if Chime forget about Mute just play a recording of me telling our account rep at AWS this is why I won't work there).

This is a better write up than I can do. https://hackaday.io/project/177896-remutermcs