I have hundreds of keyboard shortcuts memorised for things, and I use a QMK programmable Moonlander keyboard with even more.
The real advantage of this is that it also is something my family can easily use.
The opposite of this is why I like i3. Want to use my computer? Good luck: there's no start button and you'll have to guess the chord to open rofi.
To avoid collisions I'll often bind a single key to something like "Control + Shift + Alt + Meta + F14". No application I'm aware of goes hirer than F12 and most keyboard combos require a max of 3 keys. By binding such a ridiculous number of keys to one key I don't have to contort my hand too much and I can still always find the mute key.
Often the key will trigger a script, and the script will use information such as the active window to understand the exact output. (If Zoom mute is Space, if Teams it is Ctrl+Shift+M because of course it is, if Chime forget about Mute just play a recording of me telling our account rep at AWS this is why I won't work there).
This is a better write up than I can do. https://hackaday.io/project/177896-remutermcs