They are heavy and don't shift under high load. Maintenance is minimal, though. Great for a commuter but not practical for road racing or mountain biking.
Compensating for both things becomes a habit. Likewise, remembering not to shift at a stoplight becomes a habit with derailleurs. You reach a point where you begin to think like your bike.
Given that I'm a casual cyclist on a non-sporty bike, I just live with the slight awkwardness when I'm halfway up a hill and realize that I chose the wrong gear.