The Federal Government merely tolerates the states, as it derives its power from them and their delegates. But it has functionally subjugated them all and can sanction them all, almost the same way as it does to any foreign country.
The Supremacy clause is a power delegated to the Unites States by the Constitution
The Interstate commerce clause is a power delegated to the United States by the Constitution
The framers in 1790 did not predict that all commerce would be interstate commerce. Anything that the Federal Government allows to be the sole domain of the States is pure generosity, for quite some time.
The United States is a collection of states, and simultaneously a Federal Government of the same geographical shape overlaid. There is very little "federalism" or collaboration, it is Federal in name alone. Just a separate entity thats more well funded and resourceful than any individual state, or the collection of all the states.