I've recently been playing with Deno. It's early days yet but for all the general scripting tasks I might use Python for, I find Deno a better fit. First class typescript is a killer feature, as is the fact that there is a semblance of stdlib which node simply doesn't have.

My two main quibbles about Deno are:

1. The rather pointless security model that seems about as relevant as it did for PowerShell.

2. It's quite young, there's still some pointy edges.