I find that explaining virtualenvs alone quickly becomes a morass. You can skip the discussion entirely, but it is such a necessary step in good practices that it feels negligent to omit.

Not sure about what platform or level of experience you are accustomed, but I am frequently working with Windows-only users who have never even heard of PATH. Inevitably, someone needs assistance becomes something got stuck on configuring the tooling and python cannot be found. Especially fun when it is the person's N attempt at learning Python and I discover that there is a historical half-working interpreter already present.

Conda is also a huge hurdle which I try to avoid, but if I know the ultimate aim is for machine learning, gotta deal with that on-boarding.