“Bloom thinks the researchers make a good case that molnupiravir treatment is yielding some highly mutated viruses with the capacity to spread. But it’s not clear whether this could contribute to new coronavirus variants, or whether it is simply creating weakling viruses that are unlikely to spread very far.”
If it’s the former then I imagine the case is pretty strong to discontinue usage and switch to Paxlovid.
Molnupiravir is already the last line treatment, it's been that way from the start. It should never be used in cases where the patient can take Paxlovid. Well it's above Convalescent Plasma, but that's because that's barely beneficial and I don't know if anyone is even using it now.
In order of preference:
1. Paxlovid 2. Remdesivir 3. Various IV Monoclonals 4. Molnupiravir 5. Plasma
https://twiv.s3.amazonaws.com/COVID+treatment+summary+020223...
I believe Remdesivir is also one of only treatments that has any effectiveness past the first week of infection as well.