Here:
https://publications.aap.org/pediatrics/article/127/3/e20103..."It should be emphasized that fever is not an illness but is, in fact, a physiologic mechanism that has beneficial effects in fighting infection"
"and limited data have revealed that fever actually helps the body recover more quickly from viral infections, although the fever may result in discomfort in children."
"There is no evidence that children with fever, as opposed to hyperthermia, are at increased risk of adverse outcomes such as brain damage."
> that making a sick infant comfortable is not worthwhile.
Keep in mind in exchange the illness last longer. There are other ways to make a sick infant comfortable. You nurse them, you hold them, a cool cloth on the forehead helps a lot. Some babies like the vibration of a car ride, parents usually know what makes their baby happy - the hard part typically is finding time to focus on doing that. Obviously it's easier if they sleep in their crib (and for some parents that's the best option).
But what you should NOT do is think "My baby is sick I have to give the baby Tylenol!" You don't. (I've even seem parents wake their baby because it was time for the next dose!) A bit to help with comfort? OK. But the main thing is don't think you are treating their illness.