From the Stripe example: "You'd have to make deals with banks." - I know quite a few people who would love nothing more than the challenge of getting big banks to sign on to a new payment service. Their passion is selling. The harder the sell the bigger the challenge. Just like good hackers want to work on hard technical problems great salespeople like to work on hard sales problems.
The real takeaway here is that you should find your personal schlepps and start a company with someone who is passionate about them. If a great hacker, a great salesman and a great fraud investigator started a company they would be able to start a company like stripe. And they'd all be doing stuff they were passionate about.