What about hunter gatherers? Even in the history of our more recent western ancestors, people have always made radical decisions to live lives outside of the mainstream. Religious fanatics and martyrs come to mind.
> "A relatively short life full of painful loss and physical suffering, living in a rat's cage" would be a better description of the median serf.
You are leaving out the part I said about profound meaning. Mental suffering matters as much as physical suffering and a lack of meaning is a sure cause of mental suffering and is experienced by many if not most modern information workers to varying degrees.