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Immune system isn’t just too much or too little. Can’t simplify it to that. People with autoimmunity are also immunesuppressed at baseline.

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Your sort of correct. Lots of drugs like plaquninal are immune modifiers not suppressant.

However shoving large amounts of sugar and basically everything in the American diet is a great way to get the immune system to decide that everything in body is the enemy.

Sugar is pro-inflammatory, and so is omega-6 fatty acids, the consumption of both of which has increased massively within the last 60-70 years. Omega-6 fats have gone from less than 5% of human diet to up to 30% today, thanks to the commercial success of 'vegetable' oils. These two alone probably represent the most conspicuous diet changes that have happened in our societies in recent history and should be obvious suspects when looking at disease factors, imho.

The biggest change in the human diet is the explosion of cheap calories on the food market, especially hyper palatable ones.

If canola oil or even just linoleic acid were so bad for us, we could cause worse health outcomes by intervening them into diets, but that’s not what happens in RCTs.

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