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Comment by occamrazor | Hacker News Reader

I remember reading (can’t find the source anymore) that ether would work as knock-out drug, and that indeed it was used as a plot device in crime books as chloroform is used in movies today. The problem is that ether can be highly toxic at relatively low dosage, and then it was replaced by chloroform in fiction to avoid giving dangerous ideas to people.

Is there any truth behind this theory?

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Weirdly enough, ether can be drank. Erowid has a great many self-reported case studies of the effects of ether drinking

https://erowid.org/experiences/subs/exp_Ether.shtml

I've never consumed or inhaled it myself. However from someone who I know drank it, said the high is rapid and intense. Basically, it's enough to get you arrested for a public intox, and by the time you're at the police station, you're completely sober, save for your breath smelling like gasoline.

Another source about consumption of ether in 19th c Ireland : https://www.newscientist.com/letter/mg19125630-800-bring-bac...

https://www.mayoclinicproceedings.org/article/S0025-6196(11)...

https://en.wikipedia.org/wiki/Ether_addiction

As a final edit: It's probably a really bad idea to inhale or drink ether.. but it is definitely drinkable.

“The only thing that really worried me was the ether. There is nothing in the world more helpless and irresponsible and depraved than a man in the depths of an ether binge. And I knew we'd get into that rotten stuff pretty soon. Probably at the next gas station.” ― Hunter S. Thompson

Ether and chloroform both have relatively narrow therapeutic windows - the toxic dose is very close to the minimum active dose. But they were one of the few true anaesthetics at the time (late 1800s). Alcohol was also used for surgery but it's slower and inhibits clotting. In fact often it'd be a combination of all three, known as ACE [1]. This worked okay-ish, as the GABA-ergic synergy was able to suppress consciousness and memory without poisoning the patient's heart or liver (as) severely.

The other big issue was flammability.

Ether still takes enough time to reduce consciousness that you have a good minute or two (minimum) of struggle. It's not "towel over face, muffled screaming, then sleepytime". But an attacker with advantage of surprise and a decent grapple could usually get the target dosed before they could break free.

[1] https://en.m.wikipedia.org/wiki/ACE_mixture

I've heard that grayanotoxin was uses for surgery around that time frame as well.

Just some anecdotal evidence to support what you're saying.

When I was in college and a freshman, I was told the urban legend about the "ether bunny". The story about a freshman who finds out his roommate has been drugging and having sex with him using ether.

I wasn't very knowledgeable about these stories or urban legends in general so when I was home for Christmas vacation, I told my Dad about it, and he started laughing and said it was an old college urban legend but when he was told it (in the 1960's) as a freshman they used chloroform instead of ether. He mentioned some other details about the story that were changed due to the times, but that was one point that was clearly changed over time, possibly for the same reason.

However, drink 'spiking' for the same purpose is a thing, and people have been jailed for it.

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