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SuperSandro2000

My very personal recommendation: You don't, at least on a single user machine. Instead you use one of the many dotfile managers out there and for anything package related NixOS. home-manager makes the feedback loop for editing configs managed through it very long, which slowed me personally down a lot. One place where I would recommend home-manager is, if you are not using NixOS and only manage your packages through it.

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a lot of software support including configuration files, so what I do is that my configuration has a permanent configuration and a temporary configuration through including a "local" file. This even helps as a workaround to managing secrets for some stubborn stuff to which you need to put some api key or password on a text file (shitty software exist). Otherwise, I haven't seen much problem with managing home with home-manager. I also can load the same config with the nixos and darwin modules.

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