At best the worst case downside is limited, but so to is the amount of power generated.
"Stationary Low-Power Reactor Number One, also known as SL-1 or the Argonne Low Power Reactor (ALPR), was a United States Army experimental nuclear reactor in the western United States at the National Reactor Testing Station (NRTS), later the Idaho National Laboratory, west of Idaho Falls, Idaho. It experienced a steam explosion on the night of January 3, 1961, killing all three of its young military operators, and pinning one of them to the ceiling of the facility with a reactor vessel plug. The event is the only reactor accident in U.S. history that resulted in immediate fatalities.
(I don't know enough about this to know if nuclear will have a large impact, in the grand scheme).
If the reward is high enough the risk might be justified. Personally I doubt it (mostly because economically solar + wind + power storage seems like a better bet), but that's a whole other discussion.