Agree, ducts are wonderful! If you don't have ducts, go ductless for sure.
But I want to know if there is a way uneven spots could cause a problem without some effect tanking the average. What do uneven spots themselves do?
[edit: add link]
[0] https://www.energyvanguard.com/blog/Flat-or-Lumpy-How-Would-...
No, you can go to ducts by installing them. I believe the comment is advising against doing so.