The only issue I've really had is libc vs musl for some of my dependencies.
Its _tiny_ compared to ubuntu.
I haven't looked at daily driving it because it doesn't feel like it's really meant for desktop use (although I'm sure it'll work), Something like arch makes more sense if you want something more lightweight while also having decent documentation and support for desktop use, and better packaging for things like chrome, vscode, etc. Especially because of musl I suspect you'll run into a lot of issues in general.
EDIT: Also most images like python have alpine variants now which is really nice.