Wild mice have different genetics than those fed mouse chow for generations, and bred for economic production.
Unless inbreeding somehow made these lab animals immune from toxicity they are still good models.
If you take a wild mouse, and feed it, it'll live a long time, the lab mice will eventually get cancer everywhere, and die of cancer. (or so the claim goes)
I’d be interested to read it.
Example: https://journals.sagepub.com/doi/full/10.1177/10915818211009... Telomere Length and Arsenic: Improving Animal Models of Toxicity by Choosing Mice With Shorter Telomeres
The abstract discusses telomere length and sensitivity to arsenic toxicity.
If my understanding is wrong, I'd be interested in guidance to correct it. I'm interested in understanding how things really work, and Weinstein's explanations (before the Covid thing hit) made sense of otherwise paradoxical facts.
I thought they were bred atypically so that they could serve as a uniform test environment? (Zero expertise in this field.)