Lets not forget that Valve was one of the early adopters of loot boxes with Counter Strike and TF2.
1. Loot was cosmetic or a "sidegrade" of items that could be obtained through other means (especially TF2). That is, not pay-to-win.
2. Loot boxes and their contents can be sold on the marketplace, so there are opportunities to make your money back if you get a $400 item. You can also sell the boxes themselves without paying for keys. Free Steam credit for everybody.
To phrase this difference (and hopefully less ambiguously)
All items, other than cosmetic-only items are obtainable via relatively reasonable gameplay.
You can purchase non-cosmetic items, and you can purchase (lootbox gamble for) otherwise non-obtainable items.