95% of the time if I'm making nix a dependency it's just to install the correct version of python and poetry, then I let poetry handle the other dependencies. So it's totally possible to just use nix a little. My coworkers haven't even noticed the flake.nix in our repo, they just install those things by hand.

But then there's that 5% case where you do have to forge a demonic pact with the nix gods, and it's handy to have your summoning circle all warmed up and ready to go.