If prohibition didn't do anything then we should surely drop it. And then?
But, your comment seems to indicate you are more interested in legal ways you can use them than recognizing the lives that have been damaged.
Pumping money into education about the pros and cons of recreational drug use would likely do a lot to reduce abuse and addiction. However only talking about the harms was already tried and was a failure. Most kids will at least try alcohol or marijuana or vaping nicotine and if you've already lied by omission about the pros they won't trust you anymore. But if you can manage to educate in an unbiased and scientific way that would likely lead to fewer lives damaged. Worth a try at least.