Speaking of malaria, after googling for 3 minutes it seems he spent around 2B$ on it. Does it really matter? Yes and no. Maybe it had impact on people's lives, but given Gates' net value is 100B$+, giving away a billion or two does not matter. It will not affect his quality of life in any significant way. He could give away a few dozen billions more and still will spend rest of his life living in luxury that I could only dream off. Sure, better to fight malaria than buy another yacht, but still, it's easy decision to make when you have that much money.