I've experimented a lot with my diet and slowly figured out which food combinations work and do not work for me. And it is much less intuitive than anyone would assume. I used to eat a certain kind of junk food that is on the "definitely bad for you" list and I would always lose weight on it. I know it's still bad in other ways, but it made me question why I was trying so hard and still failing, while some junk food made it effortless.
It's something that the "calories in calories out" crowd really loves to dismiss outright.