Fedora Silverblue certainly seems popular here. I use it regularly and it’s been solid. I’m not sure how many people use Silverblue, but I recommend evaluating it!
The hard/fun part is just figuring out a way to install and use the software you want without doing that, since that kind of defeats the purpose of using silverblue in the first place. In most cases, you can use a flatpak, a toolbox, or a container.
However, if you can't figure it out, there's no real harm in giving up and layering whatever you want.