Pff, try "1st ave", "1st avenue south", and "1st ave N.". Yup, 3 different (albeit connected) streets in Seattle.
to answer the OP, those directionals are required to uniquely identify addresses in Seattle: http://en.wikipedia.org/wiki/Street_layout_of_Seattle#Direct...
note that they're prefixes for east-west streets, but suffixes for north-south avenues.
I've lost deliveries before when I've omitted the directional, even if the street #/street name was unique to the zip code.