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Is what you want not Guix Home? https://guix.gnu.org/manual/devel/en/html_node/Home-Configur...

Yes, Guix does not support non-Free software. However, nothing prevents you and others from supporting it. I'm fact, it can be and is distributed through channels. If I recall, this is the most prominent: https://gitlab.com/nonguix/nonguix

I think they are asking for MacOS support (which Nix supports). Not possible with Guix except through a VM.

I thought like that, but after using Guix and Nix I feel like those unified configurations are onto something. Launch your entire system from a sigle config file, avoid forgotten commands

Yes, this is what I use Nix for.

I’m saying I wanted to use Guix but I have MacBooks that I need to support, and Guix doesn’t support Darwin (the macOS system) so I went with Nix.

That is likely going to be its Achilles heel :-/