The only areas in CS that come close to that in terms of difficulty are discrete math/algorithms related ones and the CS chairs that are involved in such research also tend more towards the applied side of those topics. Really theoretical discrete math stuff resides in math departments most of the time.

Still, having also taken some discrete math classes, in terms of difficulty those somewhat paled in comparison to differential geometry/topology/abstract algebra kind of stuff. I can't even imagine how difficult it must be to be doing research in those areas.