Well I'm sorry to be a broken record, but I think the best answer is to switch to a browser (and/or browser engine) that isn't trying to kill content blocking & user choice for profit.
If only we lived in an ideal world.
But we do not, and we need to work with what we have.
I do use Firefox for all my personal browsing, but on my work machine I am more or less required to use Chrome.
And it's not even a Manifest v2/v3 issue for me, but our corporate security policies include a whitelist of allowed extensions, and ad blockers are not on the list.
Don't get me started on how dumb that is from a security standpoint, given the crap that can sometimes come in via ad networks, but it is what it is.
Manifest v2 works and while there's a minority of user effected by scrupulous extensions the vast majority of the time it works fine.