Yes it has made a difference. In white-collar crimes, prosecutors have to prove intent. That means they have to somehow find evidence that the defendant meant to do various things improperly. SBF has literally given interviews where he has stated the required intent for some of the crimes.

As an unrelated aside, note that this is also a way of punishing lower classes of people more severely. If you shoplift, prosecutors don't have to prove you meant to do that rather than just accidentally failing to pay. Generally laws for intent are for people that legislators can identify with, and there is no intent requirement for people legislators don't personally identify with.