I had a base-hit acquisition and probably could have turned around and done another VC- or self-funded startup. The burnout was too much. After a hiatus I opened a bike shop this year. I can't imagine going back to writing software for money again (I still do it on the side).
Every bike industry vet I've talked to feels about bikes the way I feel about software. Broken industry, yada yada. Anything can wear you down.