"He only gave himself a 20 percent chance of success, but, in his mind, SBF needed extreme risk to maximize the expected value of his lifetime earnings—and, therefore, the good his earn-to-give strategy could do. The fact that he was, by his own lights, overwhelmingly likely to fail was beside the point."
I guess that the whole mess boils down to a few old chestnuts - #1) Don't bet money you can't afford to lose (investors) and also that #2) you can only run at the red-line in terms of pharmacology for so long before it bites you in the arse.