There's a little bit of heaviness if they headset isn't balanced well, but that's easily fixed.
The more concerning thing is the motion sickness. Most people, at first, get nauseated after a short while, and if they don't stop using them for hours at that point, it gets worse and worse each time they use them.
However, if they stop and recover (at least a few hours, a day is better) when they first start to feel it, they'll gradually get more and more used to it.
There's also the inability to properly see things around you, like your coffee or your mouse. AR is a good fix for that, though, and Meta's new Pro glasses specifically don't have full wrap-around so that you can still see around you somewhat. It ruins immersion in games, but they aren't meant for games.
I'm a pretty big fan of VR from way back, and I've owned multiple different headsets now. I do think the "metaverse" is an eventuality, but it's not about meetings, it's about agency. Meta's current attempt at "the metaverse" is just a crappy attempt at doing better than Second Life, but without even the things that made Second Life as good as it was.
The agency to create things yourself and sell to others, and the ability to buy licensed in-universe items is pretty much essential to a functional metaverse, IMO. Meta may intend to get there eventually, but trying to sell it as "the metaverse" before that point is pointless and harmful to their goals. It's going to take a long time to get there, and I'm still hoping that a grassroots movement makes it happen first instead of a big corporation. Ready Player One was all about that scenario and what it would mean. You have to look past the cloying nostalgia to see it, of course. ;)