Just the scheduling via TimeMachineEditor so it only does backups between 2AM and 8AM or so, mostly because the Synology is audible during backups and I find that annoying when I'm in the room. I don't backup over VPN or the like, just via the local LAN (if I'm not at home, no backup gets made).

As to amount of data, I run it on my whole drive with a few excluded directories, that's 700-ish gb of non-excluded data and the backup on the Synology is 1.6TB. I've recently migrated the TimeMachine backup from an older Intel MBP to a new M2 Air (I wasn't even aware you could do that) and that seems to have worked just fine as well.