There is a self-reliance in the US which when it works seems to work ok (although even "successful" people can be very lonely), but when it breaks down very quickly leaves people with no where to turn. People often travel long distances from their families. Often relocating across the country again for work breaking whatever bonds they formed in University. People see their families once or twice a year (because the distances are so great). People prioritize economic needs over family and societal needs and this weakening of familial and societal bonds is the result. Often you end up living far from your family with a spouse and kids. If that doesn't work out - say you break up - you can find yourself alone very fast.
I feel that the homeless problem in the US is a symptom of this - although it also has many other causes. In societies with much stronger societal bonds, people don't let people live on the streets.
I don't have a solution for it, it's just something I've noticed and think about a lot when I listen to stories like this one. And don't get me wrong. Every country has problems like this. It's very easy to get isolated in large crowds of people, I just think the US has a pronounced case of it.