In many countries, you can not give up your right to sue. For example in Australia, when you go skating and there is a sign "Skate at your own risk" it means nothing.
In general, you cannot in the U.S. sign a blanket waiver giving up your right to sue. Waivers are generally narrowly construed to limit their scope to what the parties foresaw, and some types of waivers are just void as against public policy. For example if you sign a waiver of liability when you go skydiving, it might protect the skydiving company against a suit if you land the wrong way and sprain your ankle, but it won't protect them against a suit if the pilot was drunk and the plane crashes.
(Note: not legal advice, and possibly only relevant to the US)