It is supported by the fact that the brain shows dimorphism which can go wrong in many ways due to stressors, environment or genetic factors and therefore alter neurotypical development .
I'm sure a lot of people well have damaged neurotypical development if someone, who is clearly "he" would eventually let everyone around call him "she" or whatever. If gender is social construct we are "it". Sorry, I'm not playing this game, it is quite boring actually.