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> Otherwise Downs syndrome would be its own gender.

Downs syndrome doesn't affect a sex chromosome, while those other ones do? And they affect the presentation of sexual characteristics?

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All chromosomes are passed down through sexual reproduction. Chromosomal aberration, of sex chromosome or not, does not result in people of a different sex. Chromosomal aberration of sex chromosomes often results in underdeveloped sex organs and infertility, but a wan with Turner syndrome still has a uterus. XXY and XYY boys are still have penises. These are not different genders.

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