Across the wings yes but not across the majority of the fuselage.
just take some fuselage barrel sections out. Boom dash 8. Want an even smaller one. Take more sections out. Dash 7. Need a huge massive super long range one with loads of seats. Add sections and you get the dash 10 or 11.
Current planes use a uniform fuselage structure for this reason. You're going to make different models within the same model family with a flying wing.