That said, I was working on B-2 aerostructures in the late 80s, and I can tell you that most all the parts on that plane have no symmetry in any direction other than centerline bilateral. My group figured we could save over $10 million each on a single B2 duct, if we could change the bizarre geometry to simplify the scary complex tooling it required. That was enough potential savings to provoke a design review, but the answer came back, "Nope. It has to be that way (we presumed for stealth). Go figure out how to build it..."
just take some fuselage barrel sections out. Boom dash 8. Want an even smaller one. Take more sections out. Dash 7. Need a huge massive super long range one with loads of seats. Add sections and you get the dash 10 or 11.
Current planes use a uniform fuselage structure for this reason. You're going to make different models within the same model family with a flying wing.