The application registers a proper filesystem driver, so it integrates everywhere, incl. Disk Utility and other tools. So you can use it like any other filesystem. Check, format, mount, partition, etc.
For data you really care about, it's probably best to use the HFS driver for Linux or the EXT4 driver for Mac, depending on which OS you use more, and where performance is more important.
Too bad we never got FAT64
If I need to expand storage or keep a hard backup, I dedicate drives to specific machines. If I need to move files between machines, I move them over the network.
I have an external drive for a media library, storing there videos I'd like to watch and audiobooks I'd like to listen. Over years, it's grown pretty large. I'd like to have read/write access to the library from either a Macbook or a linux laptop. The linux laptop is old, and might die soon; and I am not sure whether I'll be replacing it with another linux laptop, or will switch to the Macbook entirely. I know that some people recommend getting an NAS drive; but I don't have appropriate setup for it.