Ryzen 5000 didn't have USB4 (TB3) support so that was a no-go - Framework uses 4 x Burnside Bridge ( JHL8040R) TB4 re-timers [1], one for each of their expansion module plugs. Ryzen 6000 uses Kandou retimers, which is probably a much bigger lift than plopping 12th Gen in (looks like the PD controller was refreshed (and the RTC fixed) but basically the rest of the board stayed the same [2]).
I think one thing to keep in mind also is that for whatever reason, 10 months after launch, the number of Ryzen 6000U laptops I've ever seen advertised for sale I can count on one hand (I was watching all year, I would have much preferred a Ryzen 6800U laptop!). Currently, only the Asus Zenbook S 13 and Lenovo ThinkBook 13s are available in retail stores in the US (Amazon and Newegg, respectively). In the EU, Geizhals search turns up exactly 1 6800U model (Lenovo Yoga 7 14ARB7). [3] Personally, I'm not convinced Ryzen 6000U ever actually shipped in quantity...
[1] https://github.com/FrameworkComputer/Mainboard/blob/main/Ele...
[2] https://github.com/FrameworkComputer/Mainboard/blob/main/Ele...
[3] https://geizhals.eu/?cat=nb&xf=6751_26&asuch=6800u&bpmin=&bp...