Off the top of my head:

- Understand the event loop to avoid blocking

- Understand the JIT compiler to write compiler optimization-friendly code

- With Typescript: speed up build and dev times using the SWC compiler, understand which types take more compilation time

- Minimize heap allocations to avoid memory leaks: https://blog.appsignal.com/2022/09/28/minimize-heap-allocati...

- Write native modules when you need CPU intensive operations (the official doc is quite good: https://nodejs.org/api/addons.html)

- Take care of node_modules (e.g. https://mainmatter.com/blog/2022/09/29/pnpm/)

- With Docker: optimize docker image to only include what you need. E.g. use Alpine if you don't have any particular external dependencies