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Comment by tomcam | Hacker News Reader

Thank you. Any help for insomnia or overeating?

(This is not medical advice and I am not a doctor) I don't think ketamine is directly indicated overeating, and I know esketamine isn't for insomnia or overeating. That said, There do seem to be a handful of papers studying the use of ketamine in things that affect sleep, like circadian rhythm [0][1]. In general, ketamine causes sedation in about 70% of those treated with it. Though that is short acting (hours) it may help set an individual for a good sleep, and to the extent that insomnia or overeating are caused by or co-occurrent with depression, ketamine could likely help.

[0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866161/ [1] https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.1423

Overeating might be helped by knowing your own body's blood sugar response to carbs. Take a browse through Tim Spectors ZOE. Hope you get some progress.

If you're struggling with sleep and "turning the lights off" around bed time - we made a custom natural sleep product for high performers focused on quality, restful sleep - https://impossible.co/products/sleep

Shoot me a DM if you want to try it out - happy to send one your way.

> Why Melatonin is Bad For You (coming soon).

I am curious to read why this is bad. My doc thinks this is perfectly fine

Going out on a limb here, but I’m assuming it’s meant to be “why [exogenous] melatonin is bad for you”.

Melatonin is naturally secreted by the pineal gland, which like other hormones gets downregulated when taken exogenously over long periods of time.

There’s also studies showing a downregulation in dopamine and seratonin with long term use of melatonin.

Ah - here's the link - https://impossible.co/blogs/health/melatonin-side-effects

This is just magnesium and l-theanine

Yes - they're both great compounds for helping improve sleep performance - (which unlike knockout pills you can improve over time). Most of our customers tracking their sleep with an Oura ring, Whoop band, or Eight sleep see improvements in both their scores and energy levels when adding our product to their nightly routine.

- https://impossible.co/blogs/health/magnesium-and-sleep - https://impossible.co/blogs/health/l-theanine-for-sleep

Insomnia: Have you heard Andrew Huberman’s podcast episode on sleep?

https://hubermanlab.com/sleep-toolkit-tools-for-optimizing-s...

There are so many small things you can do, and they get summarised here. Drugs are just one dimension.

Thanks . Love Huberman. Done almost everything to no avail! One thing I haven’t done is sauna and I just got one.

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