First I used AdBlock and FlashBlock.
Then I used AdBlock and NoScript.
Then I stopped using AdBlock. What a shock that was. NoScript would still catch the nasty stuff and block those talking Flash ads, but it was much less noticeable.
I don't use an adblocker now because it makes me feel out of touch with the reality of the regular user. I've been reconsidering lately, due to the proliferation of web crapware like Facebook like and Tweet buttons.
Ideally, I'd like something that blocks the incessant tracking of my web usage, uses aggressive caching and placeholders to boost performance but still lets me see the web as the regular users see it.